Port Moresby Medical Laboratories (POMMEDLAB)

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Question 1. What is CA125?

CA125 stands for cancer antigen-125. It is a glyco-protein produced in ovaries or peritoneum only in very small quantities normally. It is barely detectable in blood in normal person. Patients with cancer of ovaries produce excess amounts of CA125 and this overflow into peripheral blood and can be detected using antibody against CA125. Hence, CA125 can be measured to diagnose ovarian cancer.  Following treatment of cancer CA125 can help monitor response to treatment and detect early recurrence of cancer. 

 

Question 2. When should I request CA125?

If you have any of these symptoms or complaints, you should have your CA125 levels checked to exclude ovarian cancer:

Had previous Ovarian Cancer– detect recurrence

Strong Family history of ovarian or breast cancer

Recurrent Urinary infection

Unexplained recent weight loss

Changes dietary habits e.g. Loss of appetite, nausea or vomiting

Abdominal fullness

Abdominal swelling

Altered bowel habits

Unexplained fatigue and lethargy

Liver enlargement

Jaundice

Question 3. How is CA125 measured?

CA125 is measured on a small sample of blood. Specific antibody is used to trap CA125 from serum and level is quantified and reported. For most patients only one tube of blood is needed for all the tests. Fasting is not needed and no special preparation is required prior to sample collection.

Question 4. How long should I wait for the test report?

The testing takes up to 24 hrs depending on laboratory workload. You may return to our Result Review Center or see your doctor on the next appointment day for discussion of results. Patient or doctor will be contacted for urgent results. All reports are kept confidential and only accessed by patient or his/her doctor.  

Question 5. What does the test report mean?

The CA125 result is reported quantitatively. You will be advised of any positive report and need for further investigation or repeat testing. False positives occur in small number of patients with benign conditions. Hence, you should see your doctor or see our clinical Pathologist for further explanation on test results.